Procyclidine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Procyclidine 是一种有效的抗胆碱能化合物，还具有 NMDA 拮抗剂特性。

Procyclidine is a potent anticholinergic agent and also have NMDA antagonist properties.(In Vivo):Procyclidine (subcutaneous injection, 0.3-6.0 mg/kg) hydrochloride in combination with physostigmine (PhS) increases protection in a dose-dependent manner in rats and guinea pigs infected with soman and can prevent seizures altogether.

——

Procyclidine (subcutaneous injection, 0.3-6.0 mg/kg) hydrochloride in combination with physostigmine (PhS) increases protection in a dose-dependent manner in rats and guinea pigs infected with soman and can prevent seizures altogether. Animal Model:Male Sprague-Dawley rats, Dunkin-Hartley male guinea pigs Dosage:0.3-6.0 mg/kg Administration:Subcutaneous injection; once Result:Increased protection, resulting in 1.92, 2.24, 3.95 and 5.07 fold in rats, 3.00, 3.25, 4.50 and 4.70 fold in guinea pigs at the doses of 0.3, 1.0, 3.0 or 6.0 mg/kg, respectively.Protected the neurological integrity of the brain and prevented Soman-induced severe brain damage in the hippocampus, cortex, amygdala and thalamus.

(±)-Procyclidine hydrochlorid

Membrane Transporter/Ion Channel

NMDAR

NMDA receptor

Neurological Disease

Parkinson's disease

1508-76-5

323.9

C19H30ClNO

>98% (HPLC)

DMSO: 10 mg/mL

Cl.OC(CCN1CCCC1)(C1CCCCC1)c1ccccc1

1-cyclohexyl-1-phenyl-3-pyrrolidin-1-ylpropan-1-ol;hydrochloride

(-20℃)

With Ice Pack

≥ 2 years